CA1232800A - Veterinary implants - Google Patents
Veterinary implantsInfo
- Publication number
- CA1232800A CA1232800A CA000472907A CA472907A CA1232800A CA 1232800 A CA1232800 A CA 1232800A CA 000472907 A CA000472907 A CA 000472907A CA 472907 A CA472907 A CA 472907A CA 1232800 A CA1232800 A CA 1232800A
- Authority
- CA
- Canada
- Prior art keywords
- melatonin
- implant
- active ingredient
- veterinary
- veterinary implant
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 239000007943 implant Substances 0.000 title claims abstract description 75
- YJPIGAIKUZMOQA-UHFFFAOYSA-N Melatonin Natural products COC1=CC=C2N(C(C)=O)C=C(CCN)C2=C1 YJPIGAIKUZMOQA-UHFFFAOYSA-N 0.000 claims abstract description 59
- DRLFMBDRBRZALE-UHFFFAOYSA-N melatonin Chemical compound COC1=CC=C2NC=C(CCNC(C)=O)C2=C1 DRLFMBDRBRZALE-UHFFFAOYSA-N 0.000 claims abstract description 59
- 229960003987 melatonin Drugs 0.000 claims abstract description 59
- 239000004480 active ingredient Substances 0.000 claims abstract description 25
- 239000000203 mixture Substances 0.000 claims abstract description 22
- 239000008280 blood Substances 0.000 claims abstract description 15
- 210000004369 blood Anatomy 0.000 claims abstract description 15
- 150000002475 indoles Chemical class 0.000 claims abstract 3
- 241001465754 Metazoa Species 0.000 claims description 30
- 238000000034 method Methods 0.000 claims description 30
- 230000001488 breeding effect Effects 0.000 claims description 20
- 238000007906 compression Methods 0.000 claims description 18
- 230000006835 compression Effects 0.000 claims description 18
- 239000003979 granulating agent Substances 0.000 claims description 10
- 150000001875 compounds Chemical class 0.000 claims description 9
- 239000011230 binding agent Substances 0.000 claims description 8
- -1 fatty acid salt Chemical class 0.000 claims description 7
- 150000002605 large molecules Chemical class 0.000 claims description 7
- 239000001856 Ethyl cellulose Substances 0.000 claims description 5
- ZZSNKZQZMQGXPY-UHFFFAOYSA-N Ethyl cellulose Chemical compound CCOCC1OC(OC)C(OCC)C(OCC)C1OC1C(O)C(O)C(OC)C(CO)O1 ZZSNKZQZMQGXPY-UHFFFAOYSA-N 0.000 claims description 5
- 229920002678 cellulose Polymers 0.000 claims description 5
- 239000001913 cellulose Substances 0.000 claims description 5
- 229920001249 ethyl cellulose Polymers 0.000 claims description 5
- 235000019325 ethyl cellulose Nutrition 0.000 claims description 5
- 229920000036 polyvinylpyrrolidone Polymers 0.000 claims description 5
- 239000001267 polyvinylpyrrolidone Substances 0.000 claims description 5
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 claims description 5
- 229920000623 Cellulose acetate phthalate Polymers 0.000 claims description 4
- 239000001506 calcium phosphate Substances 0.000 claims description 4
- 229910000389 calcium phosphate Inorganic materials 0.000 claims description 4
- 235000011010 calcium phosphates Nutrition 0.000 claims description 4
- 229940081734 cellulose acetate phthalate Drugs 0.000 claims description 4
- 235000014113 dietary fatty acids Nutrition 0.000 claims description 4
- 239000000194 fatty acid Substances 0.000 claims description 4
- 229930195729 fatty acid Natural products 0.000 claims description 4
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 claims description 4
- 229920002301 cellulose acetate Polymers 0.000 claims description 3
- 229920000609 methyl cellulose Polymers 0.000 claims description 3
- 239000001923 methylcellulose Substances 0.000 claims description 3
- 235000010981 methylcellulose Nutrition 0.000 claims description 3
- 239000008188 pellet Substances 0.000 claims description 3
- 229920002554 vinyl polymer Polymers 0.000 claims description 3
- 239000001993 wax Substances 0.000 claims description 3
- 239000000546 pharmaceutical excipient Substances 0.000 abstract description 6
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 11
- 238000004519 manufacturing process Methods 0.000 description 11
- 239000008187 granular material Substances 0.000 description 10
- 238000005550 wet granulation Methods 0.000 description 10
- 238000009395 breeding Methods 0.000 description 8
- 230000000694 effects Effects 0.000 description 8
- 239000000314 lubricant Substances 0.000 description 8
- 230000001932 seasonal effect Effects 0.000 description 8
- 241001494479 Pecora Species 0.000 description 7
- 241000283903 Ovis aries Species 0.000 description 6
- 239000002253 acid Substances 0.000 description 6
- 238000005469 granulation Methods 0.000 description 6
- 230000003179 granulation Effects 0.000 description 6
- 150000003839 salts Chemical class 0.000 description 6
- 239000003826 tablet Substances 0.000 description 6
- 241000283707 Capra Species 0.000 description 5
- WHNWPMSKXPGLAX-UHFFFAOYSA-N N-Vinyl-2-pyrrolidone Chemical compound C=CN1CCCC1=O WHNWPMSKXPGLAX-UHFFFAOYSA-N 0.000 description 5
- 235000013871 bee wax Nutrition 0.000 description 5
- 239000012166 beeswax Substances 0.000 description 5
- 102000003946 Prolactin Human genes 0.000 description 4
- 108010057464 Prolactin Proteins 0.000 description 4
- 238000002474 experimental method Methods 0.000 description 4
- 229940097325 prolactin Drugs 0.000 description 4
- 230000007423 decrease Effects 0.000 description 3
- 235000013305 food Nutrition 0.000 description 3
- 239000004615 ingredient Substances 0.000 description 3
- 239000007788 liquid Substances 0.000 description 3
- 230000002611 ovarian Effects 0.000 description 3
- 241000894007 species Species 0.000 description 3
- 241000283690 Bos taurus Species 0.000 description 2
- 241000282994 Cervidae Species 0.000 description 2
- 241000270722 Crocodylidae Species 0.000 description 2
- 229920003075 Plasdone™ K-29/32 polymer Polymers 0.000 description 2
- 229920003072 Plasdone™ povidone Polymers 0.000 description 2
- RJKFOVLPORLFTN-LEKSSAKUSA-N Progesterone Chemical compound C1CC2=CC(=O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H](C(=O)C)[C@@]1(C)CC2 RJKFOVLPORLFTN-LEKSSAKUSA-N 0.000 description 2
- 241000282849 Ruminantia Species 0.000 description 2
- 229910052784 alkaline earth metal Inorganic materials 0.000 description 2
- 230000033228 biological regulation Effects 0.000 description 2
- 230000036765 blood level Effects 0.000 description 2
- 230000003111 delayed effect Effects 0.000 description 2
- 238000007907 direct compression Methods 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 229920003023 plastic Polymers 0.000 description 2
- 239000004033 plastic Substances 0.000 description 2
- 239000000843 powder Substances 0.000 description 2
- 230000001850 reproductive effect Effects 0.000 description 2
- 229920000260 silastic Polymers 0.000 description 2
- 238000007920 subcutaneous administration Methods 0.000 description 2
- 239000000725 suspension Substances 0.000 description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
- 230000003442 weekly effect Effects 0.000 description 2
- 241000881711 Acipenser sturio Species 0.000 description 1
- 241000251468 Actinopterygii Species 0.000 description 1
- 102000009027 Albumins Human genes 0.000 description 1
- 108010088751 Albumins Proteins 0.000 description 1
- 241000252073 Anguilliformes Species 0.000 description 1
- 102100034613 Annexin A2 Human genes 0.000 description 1
- 108090000668 Annexin A2 Proteins 0.000 description 1
- 241000972773 Aulopiformes Species 0.000 description 1
- 241000282832 Camelidae Species 0.000 description 1
- 241000699800 Cricetinae Species 0.000 description 1
- 241000938605 Crocodylia Species 0.000 description 1
- 241000283086 Equidae Species 0.000 description 1
- FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 description 1
- 241001508691 Martes zibellina Species 0.000 description 1
- 241000282339 Mustela Species 0.000 description 1
- 241001508687 Mustela erminea Species 0.000 description 1
- 239000010022 Myron Substances 0.000 description 1
- 241001439614 Myron Species 0.000 description 1
- 241000772415 Neovison vison Species 0.000 description 1
- 239000004698 Polyethylene Substances 0.000 description 1
- 241000283984 Rodentia Species 0.000 description 1
- 241000277331 Salmonidae Species 0.000 description 1
- 241000270295 Serpentes Species 0.000 description 1
- 241000282887 Suidae Species 0.000 description 1
- 241000270666 Testudines Species 0.000 description 1
- 241000282458 Ursus sp. Species 0.000 description 1
- 241000282485 Vulpes vulpes Species 0.000 description 1
- HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 230000001070 adhesive effect Effects 0.000 description 1
- 238000013459 approach Methods 0.000 description 1
- 239000011324 bead Substances 0.000 description 1
- FUFJGUQYACFECW-UHFFFAOYSA-L calcium hydrogenphosphate Chemical compound [Ca+2].OP([O-])([O-])=O FUFJGUQYACFECW-UHFFFAOYSA-L 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 125000004122 cyclic group Chemical group 0.000 description 1
- 230000003247 decreasing effect Effects 0.000 description 1
- 230000002950 deficient Effects 0.000 description 1
- 230000001419 dependent effect Effects 0.000 description 1
- 230000000994 depressogenic effect Effects 0.000 description 1
- 235000019700 dicalcium phosphate Nutrition 0.000 description 1
- 229940095079 dicalcium phosphate anhydrous Drugs 0.000 description 1
- 238000004090 dissolution Methods 0.000 description 1
- 230000007613 environmental effect Effects 0.000 description 1
- 230000029142 excretion Effects 0.000 description 1
- 235000019688 fish Nutrition 0.000 description 1
- 239000003292 glue Substances 0.000 description 1
- 238000002513 implantation Methods 0.000 description 1
- 238000013383 initial experiment Methods 0.000 description 1
- 239000011872 intimate mixture Substances 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 229910052749 magnesium Inorganic materials 0.000 description 1
- 239000011777 magnesium Substances 0.000 description 1
- 238000007567 mass-production technique Methods 0.000 description 1
- 230000003278 mimic effect Effects 0.000 description 1
- 210000003205 muscle Anatomy 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- 150000003013 phosphoric acid derivatives Chemical class 0.000 description 1
- 229920000573 polyethylene Polymers 0.000 description 1
- 229920000642 polymer Polymers 0.000 description 1
- 229960003387 progesterone Drugs 0.000 description 1
- 239000000186 progesterone Substances 0.000 description 1
- 230000002294 pubertal effect Effects 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 210000004994 reproductive system Anatomy 0.000 description 1
- 235000019515 salmon Nutrition 0.000 description 1
- 238000004904 shortening Methods 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 238000001356 surgical procedure Methods 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- 235000015112 vegetable and seed oil Nutrition 0.000 description 1
- 239000008158 vegetable oil Substances 0.000 description 1
- 229910052725 zinc Inorganic materials 0.000 description 1
- 239000011701 zinc Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
- A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Dermatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AUPG3361/84 | 1984-01-26 | ||
| AUPG336184 | 1984-01-26 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA1232800A true CA1232800A (en) | 1988-02-16 |
Family
ID=3770485
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA000472907A Expired CA1232800A (en) | 1984-01-26 | 1985-01-25 | Veterinary implants |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US4738679A (en]) |
| EP (1) | EP0169856A4 (en]) |
| AU (1) | AU571922B2 (en]) |
| CA (1) | CA1232800A (en]) |
| GR (1) | GR850210B (en]) |
| IT (1) | IT1184879B (en]) |
| NZ (1) | NZ210873A (en]) |
| WO (1) | WO1985003227A1 (en]) |
| ZA (1) | ZA85499B (en]) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU601736B2 (en) * | 1986-05-23 | 1990-09-20 | Sanofi Sante Nutrition Animale Sa | Coated veterinary implants |
| EP0300630A3 (en) * | 1987-07-03 | 1990-03-28 | Schering Agrochemicals Limited | Melatonin for regulating animal reproduction |
| US5091185A (en) * | 1990-06-20 | 1992-02-25 | Monsanto Company | Coated veterinary implants |
| US6638963B1 (en) | 1990-12-04 | 2003-10-28 | Oregon Health And Science University | Methods for treating circadian rhythm disorders |
| EP0518468B1 (en) * | 1991-05-09 | 1999-06-30 | Neurim Pharmaceuticals (1991) Limited | Melatonin containing compositions |
| GB9301720D0 (en) * | 1993-01-28 | 1993-03-17 | Mini Agriculture & Fisheries | Method and compositions for treating anoestrus |
| AU643934B3 (en) * | 1993-02-22 | 1993-11-25 | Ceemee Signs Limited | Improved sign |
| WO1995003043A1 (en) * | 1993-07-26 | 1995-02-02 | State Of Oregon, Acting By And Through The Oregon State Board Of Higher Education On Behalf Of The Oregon Health Sciences University | Sustained release oral compositions containing melatonin |
| FR2756493B1 (fr) * | 1996-12-02 | 2001-04-13 | Delab | Dispositif d'administration locale de formulations solides ou semi-solides |
| US20020111603A1 (en) | 1996-12-02 | 2002-08-15 | Societe De Conseils De Recherches Et D'application | Device for local administration of solid or semi-solid formulations and delayed-release formulations for proposal parental administration and preparation process |
| NL2015272B1 (en) * | 2015-08-05 | 2017-05-02 | Versailles B V | Melatonin formulations and methods for preparation and use. |
| US11529310B2 (en) | 2020-12-08 | 2022-12-20 | Ruminant Biotech Corp Limited | Devices and methods for delivery of substances to animals |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3428729A (en) * | 1966-12-20 | 1969-02-18 | William R Anderson | Controlled release formulation |
| FR2271832A1 (en) * | 1974-05-22 | 1975-12-19 | Dynachim Sarl | Compsns. contg. sex hormones and their esters - for improving wt. gain in meat animals |
| US3991750A (en) * | 1975-04-28 | 1976-11-16 | Syntex Corporation | Dromostanolone propionate implant pellet useful for producing weight gains in animals and suppressing estrus in female animals |
| DE2807132C2 (de) * | 1978-02-20 | 1983-11-03 | Battelle-Institut E.V., 6000 Frankfurt | Implantierbares Pharmaka-Depot |
| US4163011A (en) * | 1978-08-28 | 1979-07-31 | Orts Richard J | Peptide compounds and compositions |
| ZA795239B (en) * | 1978-10-12 | 1980-11-26 | Glaxo Group Ltd | Heterocyclic compounds |
| US4346709A (en) * | 1980-11-10 | 1982-08-31 | Alza Corporation | Drug delivery devices comprising erodible polymer and erosion rate modifier |
| AU554142B2 (en) * | 1980-12-05 | 1986-08-07 | Schering Agrochemicals Limited | Feeding of melatonin or related indoles or indole derivatives for purpose of regulating the reproducive |
| US4576604A (en) * | 1983-03-04 | 1986-03-18 | Alza Corporation | Osmotic system with instant drug availability |
-
1984
- 1984-01-26 AU AU38111/85A patent/AU571922B2/en not_active Ceased
-
1985
- 1985-01-18 NZ NZ210873A patent/NZ210873A/en unknown
- 1985-01-22 ZA ZA85499A patent/ZA85499B/xx unknown
- 1985-01-24 GR GR850210A patent/GR850210B/el unknown
- 1985-01-25 WO PCT/AU1985/000013 patent/WO1985003227A1/en not_active Application Discontinuation
- 1985-01-25 EP EP19850900593 patent/EP0169856A4/en not_active Ceased
- 1985-01-25 CA CA000472907A patent/CA1232800A/en not_active Expired
- 1985-01-25 IT IT67074/85A patent/IT1184879B/it active
- 1985-01-26 US US06/783,954 patent/US4738679A/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| NZ210873A (en) | 1987-10-30 |
| EP0169856A4 (en) | 1986-07-17 |
| EP0169856A1 (en) | 1986-02-05 |
| WO1985003227A1 (en) | 1985-08-01 |
| US4738679A (en) | 1988-04-19 |
| IT8567074A1 (it) | 1986-07-25 |
| AU571922B2 (en) | 1988-04-28 |
| AU3811185A (en) | 1985-08-01 |
| GR850210B (en]) | 1985-05-24 |
| ZA85499B (en) | 1985-08-28 |
| IT8567074A0 (it) | 1985-01-25 |
| IT1184879B (it) | 1987-10-28 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MKEX | Expiry |